Unmodified exogenous mRNA is readily detected by innate cellular sensors, such as Toll-like receptors (TLRs), triggering inflammatory responses that prematurely curtail translation and compromise transcript stability
[DOI] [PMC free article] [PubMed] [Google Scholar] 147.Clifford T., Acton J.P., Cocksedge S.P., Davies K.A.B., Bailey S.J
Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation
3.4.1.4 Neurocognitive impairment Long-term low-level exposure to HS (1030 ppm) is linked to memory deficits, Parkinsonism, and peripheral neuropathy
Starting doses of 250 mcg daily are typical, with assessment at 4 weeks before deciding whether to continue, increase, or adjust the protocol